5F-ADB is a synthetic cannabinoid receptor agonist (SCRA) with an aminoalkylindazole structure used as an active ingredient of products sold as cannabis substitutes. This product has no known therapeutic or medical use. In different regions it is being used and abused for non-medical purposes. Furthermore, some countries have put 5F-ADB under national control.
5F-ADB is sold for research purposes only and is not be utilized for any other purposes, including, but not limited to, in vivo diagnostic purposes, in foods, in drugs, in medicinal devices, and/or cosmetics for humans and/or animals.
It’s a synthetic cannabinoid receptor agonist (SCRA). It has an indazole core, which is a common structural feature in a number of the SCRAs monitored by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) and the UNODC.
Administration and dosage
5F-ADB is mainly offered on the Internet either in the form of ‘herbal mixtures’, where the chemical has been sprayed on plant material, as a powder, or in a liquid to be used in e-cigarette devices. Based on user reports and on the dosage forms offered, the primary route of administration is inhalation either by smoking the ‘herbal mixture’ as a joint or utilizing a vaporizer, or vaping through an e-cigarette. The effects of this product are felt on doses as small as 50 micrograms on cigarettes or buds.12 Users reported strong cannabimimetic effects after smoking the drug.
Kusano et al.present a case of an acute and fatal intoxication with 5F-ADB and diphenidine. Using LC/Q-TOFMS they could detect 3 metabolites of 5F-ADB in postmortem urine. First ester hydrolysis (M1) takes place, followed by oxidative defluorination (M2) and further oxidation to the carboxylic acid (M3). Although oxidative defluorination as a first step could not be excluded, no such substance could be detected in this case.
Adverse Reactions in Humans
The acute effects of THC (and consequently cannabis) include: relaxation, euphoria, lethargy, depersonalisation, distorted perception of time, impaired motor performance, hallucinations, paranoia, confusion, fear, anxiety, dry mouth, conjunctival injection (“redeyes”), tachycardia, and nausea and vomiting. Similar effects to cannabis have been reported for SCRAs such as 5F-ADB. Compared to cannabis, severe and fatal poisoning appears to be more common with SCRAs.Poisoning may include rapid loss of consciousness/coma, cardiovascular effects (such as hypertension, tachycardia, bradycardia, chest pain, myocardial infarction, and stroke), seizures and convulsions,vomiting/hyperemesis, delirium, agitation, psychosis, and aggressive and violent behaviour.
Product Name: 5F-ADB
Cas NO: 1838134-16-9
Molar mass: 377.46 g·mol−1
IUPAC: N-[[1-(5-fluoropentyl)-1H-indazol-3-yl]carbonyl]-3-methyl-D-valine, methyl ester
Molecular Formula: C20H28FN3O3
Appearance: White Powder
Purity: Above 99.5%
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