a-PHP is a popular synthetic stimulant of the cathinone and pyrrolidine chemical classes that produces typical short-lived substituted cathinone effects such as euphoria, thought acceleration, disinhibition and ego inflation when administered.
a-PHP is structurally related to compounds such as MDPV and is one of the successors to the designer drug cathinone analog α-PVP.
a-PHP is commonly referred to as alpha-pyrrolidinyl-hexaphenone, PHP, and alpha-PHP. The IUPAC name for a-PHP is (±)-1-Phenyl-2-(1-pyrrolidinyl)-1-hexanone.
a-PHP, or a-Pyrrolidinohexanophenone, is a compound of the substituted cathinone and substituted pyrrolidine chemical classes. Its structure is comprised of hexanal bound to a phenyl ring at the 1 position and the nitrogen of a pyrrolidine ring at the 2 position.
a-PHP is the longer chain homolog of a-PVP, possessing an additional carbon on the alkyl side chain.
Tolerance and addiction potential
As with other short-lived highly dopaminergic stimulants, the chronic use of α-PHP can be considered highly addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
Tolerance to many of the effects of α-PHP develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 – 7 days for the tolerance to be reduced to half and 1 – 2 weeks to be back at baseline (in the absence of further consumption). α-PHP presents cross-tolerance with all dopaminergic stimulants, meaning that after the consumption of α-PHP all stimulants will have a reduced effect.
Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Stimulants – α-PHP can be potentially dangerous in combination with other stimulants as it can increase one’s heart rate and blood pressure to dangerous levels.
25x-NBOMe – Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
Alcohol – It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
DXM – This combination may cause increased heart rate and panic attacks.
MXE – Increased heart rate and blood pressure may occur.
Tramadol – This combination can increase the risk of seizures.
MDMA – The neurotoxic effects of MDMA may be increased when combined with other stimulants.
Cocaine – This combination may increase strain on the heart.
Synonyms :α-PHP, alpha-PHP, α-Pyrrolidinohexanophenone, PV-7
Purity :≥ 98 %
Appearance :Off-white powder