MDPV (Methylenedioxypyrovalerone)

Description

MDPV (Methylenedioxypyrovalerone)

MDPV (Methylenedioxypyrovalerone) is a novel, extremely potent synthetic stimulant substance of the cathinone and pyrrolidine chemical classes that produces states of extreme stimulant euphoria, disinhibition, and sexual arousal when administered.

MDPV (Methylenedioxypyrovalerone) is thought to act primarily as as a norepinephrine-dopamine reuptake inhibitor (NDRI) and possesses powerful euphoric stimulant qualities.

MDPV (Methylenedioxypyrovalerone) is an incredible thing that each brave person should buy and try at least once in his life. More specifically, it is a psychoactive drug that has stimulating properties, and acts like a reuptake inhibitor of dopamine and norepinephrine.

Pharmacology

MDPV is thought to act primarily as a potent norepinephrine-dopamine reuptake inhibitor. Reduced re-uptake of norepinephrine and dopamine results in higher concentrations of the two catecholamine neurotransmitters in the synaptic cleft, or gap between neurons. The result of this inhibition is an enhanced and prolonged concentration and resulting post-synaptic effect of dopaminergic and noradrenaline signaling at dopamine and norepinephrine receptors on the receiving neuron. Serotonin also plays a role, although to a much lesser degree. This sudden increase in neurotransmitter concentration in the brain is thought to be responsible for the high that MDPV produces. Mainly possessing re-uptake inhibiting qualities, MDPV could be considered more like cocaine or methylphenidate than amphetamine in method of action.In contrast, amphetamine acts primarily as an agonist to release dopamine and noradrenaline indirectly via activation of the TAAR1 receptor.

Interactions

Although many psychoactive substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Stimulants – MDPV can be potentially dangerous in combination with other stimulants as it can increase one’s heart rate and blood pressure to dangerous levels.
25x-NBOMe – Both the NBOMe series and this compound induce powerful stimulation and their interaction may cause severe side effects. These can include thought loops, seizures, increased blood pressure, vasoconstriction, increased heart rate, and heart failure (in extreme cases).
Alcohol – It is dangerous to combine alcohol, a depressant, with stimulants due to the risk of excessive intoxication. Stimulants decrease the sedative effect of alcohol which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of alcohol will be significantly increased, leading to intensified disinhibition as well as respiratory depression. If combined, one should strictly limit themselves to only drinking a certain amount of alcohol per hour.
DXM – This combination may cause increased heart rate and panic attacks.
MXE – Increased heart rate and blood pressure may occur.
Tramadol – This combination can increase the risk of seizures.
MDMA – The neurotoxic effects of MDMA may be increased when combined with amphetamine and other stimulants.
MAOIs – This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, 2C-T-2, 2C-T-7, αMT, and some antidepressants.
Cocaine – This combination may increase strain on the heart.

Side Effects

MDPV acts as a stimulant and has been reported to produce effects similar to those of cocaine, methylphenidate, and amphetamines.

The primary psychological effects have a duration of roughly 3 to 4 hours, with after effects such as tachycardia, hypertension, and mild stimulation lasting from 6 to 8 hours.High doses have been observed to cause intense, prolonged panic attacks in stimulant-intolerant users,and there are anecdotal reports of psychosis from sleep withdrawal and addiction at higher doses or more frequent dosing intervals.It has also been repeatedly noted for inducing irresistible cravings to re-administer.

Reported modalities of intake include oral consumption, insufflation, smoking, rectal and intravenous use. It is supposedly active at 3–5 mg, with typical doses ranging between 5–20 mg.